RCMP say an 89-year-old woman and a 55-year-old woman from the Wanham/Spirit River area were killed.
RCMP say the crash occurred on Highway 43 near Bezanson, east of Grande Prairie.
One of the injured was flown to an area hospital.
The others were taken to the same hospital by ground ambulance.
Police say it appears the car was crossing the highway and was struck by a pickup truck going east.
A detour around the crash site is to remain until investigators have finished.
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