The Indians ended the series with a convincing blowout, one day after they won 4-3 with the help of a blown call in the ninth inning when umpires, after watching a video replay, ruled that an apparent tying home run by Oakland's Adam Rosales was a double.
Major League Baseball acknowledged the umpires made an "improper call," but executive vice-president Joe Torre said the decision is final.
Kipnis hit a two-run homer in the first off Bartolo Colon (3-2) for the Indians, who won for the 10th time in 11 games and improved to 13-4 since April 20. Kazmir (2-1) allowed one run and five hits and has won back-to-back starts for the first time since 2010.
Josh Donaldson homered for the A's, who fell to .500 (18-18) for the first time since April 4.
TWINS 5, RED SOX 3
BOSTON (AP) — Oswaldo Arcia hit a two-run homer and Minnesota capitalized on a costly throwing error by Boston starter John Lackey to beat the struggling Red Sox.
Lackey's wild throw to second on a potential inning-ending double play gave the Twins another chance in the sixth and they responded with four unearned runs to take a 5-2 lead.
The Red Sox lost for the sixth time in seven games and fell out of first place in the AL East.
Kevin Correia (4-2) pitched 5 1-3 innings for the Twins and Glen Perkins pitched the ninth for his eighth save in eight chances.
Lackey (1-3) allowed six hits and one walk and struck out eight in seven innings.
ANGELS 6, ASTROS 5
HOUSTON (AP) — Mark Trumbo hit a two-run double in the eighth inning before Alberto Callaspo's go-ahead sacrifice fly sent Los Angeles to a win over Houston.
The struggling Angels snapped a four-game skid and avoided an embarrassing sweep against last-place Houston in a game that took 4 hours, 7 minutes — the longest nine-inning game this season.
Josh Hamilton and Brendan Harris homered for the Angels.
Garrett Richards (2-3) pitched a scoreless seventh for the win and Ernesto Frieri got five outs for his fifth save.
Hector Ambriz (0-2) took the loss.
RAYS 5, BLUE JAYS 4, 10 INNINGS
ST. PETERSBURG, Fla. (AP) — Luke Scott drew a bases-loaded walk with two outs in the 10th inning to give Tampa Bay a victory over Toronto.
The Rays loaded the bases on Evan Longoria's double off Aaron Loup (1-3) and two walks.
The game featured a rare matchup of reigning Cy Young Award winners, however David Price and R.A. Dickey were not involved in the decision. Dickey allowed three runs and five hits, walked five and struck out five in six innings for the Blue Jays. Price worked eight innings for Tampa Bay, yielding four runs — two earned— and seven hits in eight innings.
Kyle Farnsworth (2-0) pitched one inning to get the win.
ROYALS 6, ORIOLES 2
BALTIMORE (AP) — Alex Gordon and Eric Hosmer homered in a four-run fourth inning, Jeremy Guthrie pitched effectively against his former team and Kansas City avoided a three-game sweep.
Gordon and Hosmer both connected against Freddy Garcia (0-1) with a runner on.
Mike Moustakas also homered for the Royals, who snapped a three-game skid. The three home runs were a season high for Kansas City, which began the game with an AL-low 19 long balls.
Facing the Orioles for the first time since they traded him to Colorado in February 2012, Guthrie (5-0) allowed one earned run, seven hits and three walks in six innings to lower his ERA to 2.28.
Garcia retired the first 10 batters he faced before getting into trouble in the fourth.