Omran al-Zoubi says in remarks carried by state news agency SANA Tuesday that Syria will not take part in any political dialogue that infringes on the country's sovereignty.
The U.S. and Russia called last week for an international conference to start talks accompanied by a cease-fire. The two nations are on opposite sides of the Syria conflict. This marks their first serious joint attempt at Syria diplomacy in a year.
Syria's Foreign Ministry welcomed the U.S.-Russian initiative without saying whether it would attend.
The main opposition bloc, the Syrian National Coalition, said Monday it wants to consult its allies before deciding.