Slava Voynov and Mike Richards each had a goal and an assist in the defending Stanley Cup champions' 11th straight victory at Staples Center since March.
With yet another dominant playoff performance by Quick, Los Angeles opened the NHL's fourth all-California playoff series with its fifth straight victory after an 0-2 start to its title defence.
The Kings' Conn Smythe Trophy winner allowed just 10 goals in the six-game first round against St. Louis before frustrating the Sharks, whose superior speed and passing produced nothing.
Antti Niemi stopped 18 shots for the Sharks, who swept Vancouver out of the first round.
Game 2 is Thursday.
PENGUINS 4, SENATORS 1
PITTSBURGH (AP) — Paul Martin and Chris Kunitz scored power-play goals and Pascal Dupuis added his sixth goal of the playoffs and Pittsburgh beat Ottawa in Game 1 of the Eastern Conference semifinals.
Evgeni Malkin extended his points streak to seven games with a goal and an assist for Pittsburgh.
Game 2 is Friday night.
Tomas Vokoun stopped 35 shots to win his third straight start and top-seeded Pittsburgh never trailed.
Colin Greening scored for the Senators. Craig Anderson made 26 saves but Ottawa had no answer for Pittsburgh's power play.Suggest a correction