The crash happened when the truck was crossing East 1st Avenue at Nootka Street at about 10:30 p.m. PT.
Police say the 27-year-old motorcyclist died at the scene.
The 76-year-old truck driver was not injured and is cooperating with the investigation.
East 1st Avenue was closed for about six hours following the crash.
The cause of the crash has not been determined but police say speed may have been a factor.
The victim's name is not being released.