The mother, Hua Qin Zhou, and her child, Gao Yixuan, were last seen early Monday morning at a southwest Edmonton home on Mullen Road close to Rabbit Hill Road.
Police were called to the home at 7:45 p.m. and were told the mother left the home with the child between 6:45 a.m. and 5 p.m.
The baby girl is Chinese, has dark hair and a round face.
The mother is Chinese, 36 years old, 5-2", 125 pounds, with straight black hair with yellow highlights.
The mother is believed to have a stroller, baby supplies, and a large suitcase with her as she may be planning to go back to China.
Police said they are concerned for the well-being of the child.
A news conference is scheduled for Tuesday afternoon.