Winfrey's cable channel, OWN, said Friday that Winfrey is getting an "exclusive" interview with Lohan that will tape and air in August.
In May, Lohan checked into a Southern California rehab centre for a 90-day stay, part of a plea deal in a misdemeanour case filed after a car accident. She's expected to finish rehab around the end of July.
OWN says it also plans an eight-part documentary series with Lohan, to air in 2014.
The 27-year-old Lohan, whose credits include "The Parent Trap" and "Liz & Dick," has struggled with legal and other woes. OWN and Winfrey have scored ratings with other newsworthy celebrity interviews, including Lance Armstrong and Rihanna.