The fire started at around 12:15 a.m. Tuesday on Doody Street in the South Shore community.
A truck parked in a driveway beside the home ignited and the flames spread.
A man in his 50s escaped the home unharmed.
Other homes in the area were evacuated as a precaution.
Investigators haven’t confirmed what started the blaze.
The arson squad is expected on the scene later today.