It's the third death this month involving Mounties in the province.
The 52-year-old was shot at a home on the Cold Lake First Nation's reserve on Thursday and was pronounced dead in hospital.
Sarah Jackson, a spokeswoman with the Alberta Serious Incident Response Team, said the man was wanted for sexual assaults and many officers, both in uniform and plain clothes, were at the home to execute warrants.
"During the confrontation with the male, one RCMP officer fired his service weapon striking the male," Jackson said Friday.
Investigators later recovered a knife from the scene, she added.
An emailed statement from the band's chief and council expressed condolences and asked for privacy for the man's family.
"In the coming days, we will provide more information to our members as the facts and investigation are underway."
The response team, an independent body that investigates police actions that lead to serious injury or death, is also looking into the other two deaths and a non-fatal shooting in recent weeks.
On Aug. 1, RCMP pulled over a suspected impaired driver near Grande Cache northwest of Jasper. Mounties said the man behind the wheel was shot and wounded during an altercation. He fled but was caught a short time later and taken to hospital.
Family later identified the injured man as Curtis Hallock, a regular sidekick on the reality TV show "Mantracker.''
The following day, RCMP in Leduc, just south of Edmonton, used a Taser while trying to arrest a suspect in a series of assaults, thefts, driving complaints and hit-and-runs. The 27-year-old went into medical distress while in handcuffs and later died in hospital.
That same weekend, an officer pulled over another suspected impaired driver near Ma Me O Beach on Pigeon Lake southwest of Edmonton.
RCMP said while the officer tried to arrest one of five men inside the car, there was an altercation and two of the occupants were shot. A 30-year-old man from Pigeon Lake died at the scene. His 41-year-old brother was taken to hospital with chest wounds.