The Ottawa-area team representing Canada at the baseball series was eliminated by the team from Panama, 12 to 0.
The Monday evening game came after they fell to Chung-Ping Little League, this year's representative from Chinese Taipei, and after they beat a team from Brno, Czech Republic.
Teams are eliminated after their second loss.
The Eagles’ last game was only four innings long. It was shortened because of a mercy rule that kicks in if one team is up by 10 or more runs.
Jack Walsh broke Panama's attempt at a no-hitter at the bottom of the fourth.
The 16-team tournament features eight teams from the U.S. and eight international squads.
The loss wraps up an emotional season for the East Nepean Eagles, which last competed in the Little League World Series in 2004.
The Eagles represented Canada after beating a team from British Columbia, the province that has represented Canada at the series for the past eight years.