Wilson, a native of Flint, Mich., originally signed with the club in 2005 and helped the Lions win a Grey Cup in 2006. He had 70 defensive tackles and nine sacks in 36 regular-season games over two seasons with B.C.
"Chris approached us last week about returning to the club and we are very pleased to welcome him back," Lions general manager Wally Buono said in a release. "He's a gifted athlete who will bring another aggressive and physical presence to our defensive line."
Wilson signed with the Washington Redskins in 2007 and spent the next four seasons with the NFL club.
He signed with the Philadelphia Eagles in 2011 but was released in training camp and sat out the rest of the year. Wilson returned to the Redskins in 2012.
In 80 career games over five NFL seasons, he recorded 57 defensive tackles, 6 1/2 sacks and three forced fumbles.