Clark will leave on her 13-day trip to China, Korea and Japan on Nov. 21.
A government news release says her agenda includes the second annual Canada-Korea Natural Gas Forum.
The Liberals say the new mission is aimed at taking advantage of growing markets in Asia.
Clark went on a trade mission to Japan, Korea and the Philippines last year, five months after travelling to China and India.
Her former trips have involved meetings with government and business officials on forestry, mining, education and discussing ways to make it easier for skilled workers to move to Canada from the Philippines.