Calgary punter Rob Maver won the special-teams award while Saskatchewan slotback Chris Getzlaf was the top Canadian.
Reilly threw for 196 yards and three touchdowns to help the Eskimos defeat the Winnipeg Blue Bombers, 25-7. He rushed for a career-high 113 yards on nine carries, including a 45-yard run in the second quarter.
Reilly is fourth among CFL passers with 2,667 yards and also has 19 touchdowns.
Bighill recorded seven tackles and grabbed his first interception on the season to help the B.C. Lions defeat the visiting Montreal Alouettes, 36-14.
The linebacker intercepted a Josh Neiswander pass in the third quarter and returned it 44 yards to the Als' one-yard line, setting up an Andrew Harris touchdown.
Bighill is fifth overall in tackles with 52 and is tied for second on the Lions with four sacks.
Maver had five punts for 244 yards (averaging 48.8 yards) in the Stampeders' 26-22 home win over the Hamilton Tiger-Cats.
Maver, who's tied for second in the CFL with a punting average of 45 yards, also threw a 31-yard pass to Matt Walker on a fake punt.
Getzlaf recorded five catches for a game-high 135 yards and two TDs in the Roughriders' 31-29 home loss to Toronto.
He leads all Canadian receivers with 708 yards, good for fourth overall in the CFL. He's also tied for second with seven TD grabs.