Vick threw two picks and the Eagles lost two fumbles in the first half. The four turnovers were more than they had in the first two games combined. Vick also got sacked five times, including 3 1/2 by Justin Houston.
The Eagles scored 63 points and totalled 954 yards in the first two games in Chip Kelly's frenetic, fast-paced offence. But Kansas City's swarming defence had plenty of answers.
Reid was back in Philadelphia for the first time since he was fired last season following a 4-12 finish. He got a standing ovation from some of the same fans who chanted "Fire Andy" during a game in 2011 and desperately wanted him gone last year.
Reid's homecoming coincided with the Eagles retiring Donovan McNabb's No. 5 at halftime. Reid drafted McNabb with the second overall pick in 1999, and the coach-quarterback duo turned the Eagles into one of the NFL's elite teams for a decade.
Adding to the story line was the fact both teams are off to surprising starts. The Chiefs (2-0) have already matched last year's win total, while the Eagles (1-1) showed off a dynamic offence in Kelly's first two games.
Vick hadn't thrown a pick in his last 95 attempts, dating to last season, before locking in on Brent Celek on Philadelphia's third play. Derrick Johnson tipped the ball and Berry caught it, running untouched to the end zone to give the Chiefs a 10-0 lead.
Vick played near-flawless the first two games, accounting for six TDs (four passing, two rushing) and a 119 passer rating. He threw for a career-best 428 yards in a 33-30 loss to San Diego last Sunday, but only had 149 yards passing in the first three quarters against the Chiefs.
Vick bounced back from the first interception with a career-best 61-yard run before tossing a 22-yard TD pass to Jason Avant that cut it to 10-6. Vick had 85 of Philadelphia's 201 yards rushing through three.
After Vick connected with Avant, the Eagles then failed on Kelly's first attempt at a two-point conversion. Known for passing up extra points and going for 2 at Oregon, Kelly waited until his third game to try it in the NFL.
Kicker Alex Henery lined up in the shotgun, but the snap went right to Zach Ertz lined up wide to the left. Ertz was tackled well short of the end zone.
One of Philadelphia's fumbles came when centre Jason Kelce's shotgun snap bounced off his thigh, hit guard Todd Herremans and was recovered by Houston at the Chiefs 49.
After the Chiefs went three-and-out on the game's first series, Damaris Johnson fumbled the punt at the Eagles 8 and Cyrus Gray recovered. Kansas City went three-and-out again, and settled for Succop's 33-yard field goal.
Succop kicked field goals of 31 and 34 yards in the second quarter. Donnie Avery had 126 yards receiving going into the fourth.
Henery hit a 29-yarder to cut it to 16-9 in the third quarter, but later missed a 48-yarder wide left.
Reid led the Eagles to nine playoff appearances, six division titles, five NFC championship games and a loss in the 2005 Super Bowl.
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