Quarterback Wil Finch and running backs Yannick Harou and Adam Sinclair all rushed in touchdowns for Western (6-0). Finch also passed for two TDs, with Sinclair catching one of the scores.
Finch was impressive on the ground, running for 114 yards while also racking up 254 passing yards on the day.
Harou's 153 rushing yards was the most among Mustangs' running backs.
Ryan Granberg broke a career rushing record for the Gaels (4-1), hitting and surpassing the 3,000-yard plateau by rushing for 117 yards. Granberg passed Mike Giffin's record of 3,035 yards in his Queen's career.
Gaels quarterback Billy McPhee was 22-for-36 with 336 yards, one touchdown and one interception. Daniel Heslop led all Queen's receivers with 87 yards.
Also in CIS football action: McGill 53 Concordia 52 (OT); Laval 46 Bishop's 38; Guelph 41 Waterloo 19; Ottawa 46 York 16; Windsor 26 Laurier 25 (OT); Manitoba 34 Regina 15; Saskatchewan 17 UBC 12; Calgary 76 Alberta 21; and Acadia 40 Mount Allison 9.
McGill 53 Concordia 52 (OT)
At Montreal, Luis Guimont-Mota ran in a touchdown from one yard out and Samy Rassy kicked the conversion as the Redmen (3-2) slipped past the Stingers (0-5) in overtime.
No. 1 Laval 46 No. 8 Bishop's 38
At Lennoxville, Que., quarterback Alex Skinner completed 19 of 24 passes for 281 yards and two touchdowns as the top-ranked Rouge et Or (5-0) dispatched the Gaiters (3-2).
No. 6 Guelph 41 Waterloo 19
At Waterloo, Ont., quarterback Jazz Lindsey threw 249 yards and four touchdowns as the Gryphons (5-0) bested the Warriors (1-4).
Ottawa 46 York 16
At Toronto, QB Derek Wendel passed for 297 yards and four TDs as the Gee-Gees (3-3) thumped the Lions (2-3).
Windsor 26 Laurier 25 (OT)
At Waterloo, Ont., kicker Dan Cerino scored a rouge in overtime as the Lancers (4-2) edged the Golden Hawks (1-5).
No. 10 Manitoba 34 Regina 15
At Winnipeg, quarterback Jordan Yantz passed for 134 yards and three touchdowns to lead the Bisons (3-2) past the Rams (1-4).
No. 7 Saskatchewan 17 UBC 15
At Vancouver, Shane Buchanan rushed for 67 yards and a touchdown and quarterback Drew Burko put up 231 passing yards as the Huskies (4-1) downed the Thunderbirds (2-3).
No. 5 Calgary 76 Alberta 21
At Edmonton, Andrew Buckley completed 22 of 26 passes for 336 yards and three touchdowns, and running back Mercer Timmis carried for 214 yards and four TDs as the Dinos (5-0) decimated the Golden Bears (0-5).
Acadia 40 Mount Allison 9
At Wolfville, N.S., Zack Skibin rushed for 105 yards and a touchdown, and the Axemen (2-2) defence held the Mounties (1-3) to just three field goals.