Calgary's Smealinho Rama, Canada's top-ranked heavyweight, fell to Anthony Hamilton at MFC 38: Behind Enemy Lines.
After a competitive opening round that saw both fighters looking to land knockout blows, the action came to a sudden end just 12 seconds into the second round when Hamilton, a training partner of current UFC champ Jon Jones, landed a thunderous head kick that sent Rama reeling.
"He was dropping his hands and he was tired," Hamilton said. "I figured I could throw a one-two and set up the kick."
In the middleweight bout, Sam Alvey and Jason South both delivered gritty performances.
Alvey punished South with his boxing skills for the first two rounds, knocking him down several times.
With one eye swollen shut and a broken, bloodied nose, South battled back as the fight wore on.
Both men traded attacks until the final seconds of the fifth round when Alvey landed a perfectly placed right hook that finished South with just four seconds left in the bout.
"It was there, I took it. My corner kept telling me: 'Press, press, press,'" Alvey said after the bout.
The bantamweight title fight featured highly touted prospect Anthony Birchak and respected veteran Tito Jones.
Despite his underdog status Jones, put up a scrappy performance as he and Birchak battled back and forth in the clinch and in lightning fast scrambles for most of the first five minutes.
But in the second round, Birchak kept up a blistering pace and finally put Jones away with a rear-naked choke.
"I didn't want to try to punch myself out … so I went for the submission," Birchak said.
In other bouts, Aaron Gallant set a new MFC record for the fastest knockout in the promotion's 12-year history as he hit Matt Jelly with a vicious uppercut just seven seconds into the opening round.