RUSADA said in Wednesday's statement that more than 88 athletes have been punished for different violations and more than 80 other cases are still under investigation or awaiting decision.
The report comes four months before Russia hosts the 2014 Winter Olympics in Sochi.
The number of doping violations in the first nine months of the year is almost twice the number registered during all of 2013.
The statement said 13,674 urine and 3,118 blood tests were carried out. More than 50 per cent of the tests were conducted out of competition.
The statement did not specify the sports or athletes involved.