Vancouver police Sgt. Randy Fincham said police were called at around 3 a.m. PT to Au Bar Nightclub, which is in the 600 block of Seymour Street. Officers found two injured men outside.
Fincham said the men had "serious stab wounds" and paramedics took them to hospital.
No arrests were made and no suspect information was available as of Saturday morning, he said.
Investigators from the Vancouver Police Major Crime Section and the Forensic Identification Unit are working on the case.