The 36-year-old announced his retirement in a press release on Sunday.
He spent the last four seasons backing up Henrik Lundqvist in New York with the Rangers, including this season but was placed on waivers by the club and went unclaimed. Biron has also played for the Buffalo Sabres, Philadelphia Flyers and had a brief stint with the New York Islanders in 2009-10.
Biron, a six-foot-two, 186-pound native of Lac St. Charles, Que., ranks 59th on the all-time list in appearances by a goaltender with 508.
He ranks 59th in all-time wins and owns a career 230-191-27 record to go along with 28 shutouts. He has a career 2.61 goals-against average and a solid .910 save percentage.
Originally selected 16th overall in the first round of the 1995 NHL Entry Draft, Biron has five career 20-win seasons and two 30-win campaigns.