Montreal police said the woman was crossing Wood Street as the truck was making a left turn onto the street from de Maisonneuve Boulevard West.
Montreal police Const. Dany Lacoursière said witnesses told investigators the woman was running across the street when she was struck.
He said the 44-year-old driver of the vehicle was not injured.
Urgence Santé said the woman suffered severe head injuries.
The woman is believed to be in her late 40s or early 50s.