The CBC’s Jamie Strashin reported Wednesday that Brooks Barnett had left the mayor’s office.
Barnett had worked as a policy adviser to the mayor.
Ford saw a series of staff members depart his office earlier this year, after reports emerged that he had been caught on video smoking crack cocaine.
The mayor long denied the video’s existence and smoking crack cocaine.
That changed on Tuesday, when Ford told reporters that he had smoked crack cocaine.
"Yes I have smoked crack cocaine," Ford said, suggesting that he had not misled the media in previous denials as they had not asked him "the correct questions."
A few hours later, Ford spoke again reporters telling them about the "embarrassment" of admitting his drug use.
But Ford said he had a job to do and he intended to carry on as mayor.
He also said he has "nothing left to hide."
Just two days before his crack-use admission, Ford apologized for "mistakes," which he said included getting "hammered" at the Taste of the Danforth street festival and to letting things get out of control on St. Patrick's Day last year.
Ford is only three years into his four-year term as mayor. On Tuesday, he said it will be up to voters to decide if he will hang onto his job in the next election.
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