The accident occurred at about 3 a.m. in Quebec City's Neufchâtel neighbourhood, as the victim and his friend were walking home after leaving a bar.
Police said they are searching for the driver of a dark-coloured SUV, who fled the scene after hitting the man.
Investigators were on the scene early Friday morning gathering evidence to identify the driver.
Police said it does not appear the driver tried to brake before or after striking the victim.
The pedestrian was transported to hospital, but he eventually died of his injuries.
Armand Goulet, a resident on the street where the accident occurred, said he was woken by the sound of the impact.
"I heard a big boom,” said Goulet. "I called 911 and when the police arrived, they looked everywhere, but there was nothing there. There wasn't a trace.”