Jamaican Sports Minister Natalie Neita-Headley says the 12 commissioners agreed to step down to give the government what she described as "a fresh start" as it reorganizes the commission. The resignations take effect Dec. 31.
She told reporters on Friday that Jamaica would review its anti-doping legislation and appoint qualified testing officers.
Jamaica's anti-doping program was audited by the World Anti-Doping Agency after a former Jamaica director alleged it didn't drug-test its athletes for entire months before they dazzled at the 2012 London Olympics.
Eight Jamaican athletes have failed drug tests this year, including former world 100-meter record holder Asafa Powell.