RCMP said three people were ejected from the car after it veered off the side of Route 115 and crashed into a culvert.
Speed was a factor in the crash, RCMP said. The accident happened around 12:40 a.m. on Saturday. Notre-Dame is north of Moncton, N.B.
All the victims are male. Three are 18 years old, and one is 17 years old.