It's the first time trains will be travelling through the town since July's derailment that killed 47 people.
The shipment on Wednesday will contain dry goods. No oil or combustible material will be transported.
The train will have six cars and will roll through the town in daylight hours. No specific time of the day was given.
Lac-Mégantic Mayor Colette Roy-Laroche said residents are concerned about the resumption of trains.
"We've invited people to contact various psycho-social services if they need it," she said.
More to come