Highway 15 southbound is closed to traffic after Ste-Adèle. Provincial police said about 30 people are trapped inside their vehicles.
Highway 15 southbound near St-Jean-sur-Richelieu is also closed.
A blowing snow warning is in effect for the Montreal and Quebec City areas.
Another multi-vehicle collision near Lévis has closed Highway 20 eastbound, and a pile-up closed part of the highway westbound near Beaumont, east of Quebec City.