DeRozan was among those chosen as Eastern Conference reserves on Thursday but perhaps more upsetting for Raptors fans was Lowry's omission.
The six-foot, 205-pound point guard has drawn plenty of praise for his play this season in helping lift the Raptors to first place in the Atlantic Division. He's averaged 16.8 points and 7.6 assists per game, to go along with 4.3 rebounds.
DeRozan is enjoying a career year with 21.8 points and 3.6 assists per game, and has, along with Lowry, flourished since the Rudy Gay trade to the Sacramento Kings.
This will be his third appearance at NBA All-Star Weekend, but first in the actual game. DeRozan, who missed the Raptors' last two games with a sprained ankle, participated in the Sprite Slam Dunk in 2010 and 2011 and played in the 2011 T-Mobile Rookie Challenge.
Toronto centre Jonas Valanciunas was also selected to the NBA Rising Stars Challenge, averaging 10.4 points and 8.7 rebounds per game.
The Portland Trail Blazers and Houston Rockets each had two players picked as reserves for the NBA All-Star game, while the Indiana Pacers had to settle for just Roy Hibbert despite the league's best record.
LaMarcus Aldridge and Damian Lillard made it from the Trail Blazers, who have been among the Western Conference leaders all season.
Dwight Howard, who was passed late in fan voting for a starting spot, was chosen Thursday along with Houston teammate James Harden.
Old reliables Chris Paul, Tony Parker and Dirk Nowitzki round out the West reserves for the Feb. 16 game in New Orleans.
The rest of the East reserves are: Miami's Chris Bosh, Washington's John Wall, Brooklyn's Joe Johnson, Chicago's Joakim Noah and Atlanta's Paul Millsap.