The move wasn't a surprise. Dressler, 28, was scheduled to become a free agent Feb. 15 and was exploring his NFL options.
This allows Dressler, who earlier this month worked out for the Kansas City Chiefs, to sign an NFL deal immediately.
At a media conference Thursday in Regina, Dressler said he has decided to sign with an NFL team, but — on instructions from the team — will not say which one it is.
He stressed that money was not a factor in his decision, but added it was a difficult one to make.
As a nod to Roughriders fans, Dressler said he requested jersey number 13 — to denote the 13th-man associated with fan support in the CFL.
He said he did not know when an official announcement with his new team would be made, adding he needs to get a physical exam done before signing a contract.
The five-foot-eight, 179-pound native of Bismarck, N.D., has spent the past six seasons in Regina, having registered 442 catches for 6,531 yards and 43 TDs.
He has surpassed the 1,000-yard receiving plateau five times in his career, including the last four years.
Dressler had five catches for a game-high 81 yards and a touchdown in Saskatchewan's 45-23 Grey Cup victory over Hamilton.
Dressler is a two-time CFL all-star and was the league's top rookie in 2008.