The government says top golfers are expected to compete in the PGA Tour event at the Ashburn Golf Club in the suburb of Fall River from July 3-6 and again next year.
The Nova Scotia Open is the only Canadian stop on the PGA's Web.com Tour.
Tourism Minister Michel Samson says the event is expected to be televised on the Golf Channel to a potential audience of 81 million households in 192 countries.
As well, the PGA Tour Canada Cape Breton Celtic Classic will held Sept. 1-7 at The Lakes Golf Club in Ben Eoin.
Nova Scotia will be the only province in Canada to play host to two PGA Tour events this year.
The PGA Tour had previously released the schedule for its 25-event Web.com Tour before Tuesday's announcement by the province. In addition to Nova Scotia, it also added new tournaments in Oregon and Ohio.
The top 25 players on the Web.com money list earn PGA Tour cards for the following year.
The Nova Scotia Open will be held at Ashburn's new course, a 7,014-yard, par-72 layout that opened in 1970. The tournament will feature a field of 156 golfers competing for a purse of US$650,000.