The session is slated to begin at 12:45 p.m. ET. CBCNews.ca will livestream the Q&A.
Harper is expected to talk about the economy and free trade, including the recently signed Comprehensive Economic and Trade Agreement (CETA) with the European Union.
Joining the prime minister will be Éric Lavoie, chairman of the Chamber of Commerce in Quebec City. Harper is not expected to take any media questions.
The event is part on an ongoing tour across Canada involving Harper sitting down with business executives for informal discussions.
During an event with the Vancouver Board of Trade in early January, two activists sneaked up onstage behind the prime minister and held up signs to silently protest the government's climate change policies.