The 71-year-old became ill Tuesday as the cruise headed from Grand Cayman to Mexico. The ship returned to Grand Cayman and Fregosi later was transported to a Florida hospital once doctors stabilized his condition.
“He passed away at 2.36 a.m. [ET],” according to Fregosi’s oldest son, Jim Fregosi Jr. “Went in peace with no pain.”
At Fregosi's bedside when he passed were his wife Joni, daughters Nikki, Lexy and Jennifer along with his other son Robert.
Fregosi, who spent the past 13 seasons as a special assistant to Atlanta Braves general manager Frank Wren, compiled a win-loss record of 167-157 in Toronto.
He also managed the Philadelphia Phillies to the 1993 National League pennant and 1979 California Angels to their first American League West title.
Fregosi was selected 35th overall by the Angels in the 1960 expansion draft. He went to play 18 seasons in the majors for California, Texas, Pittsburgh and New York Mets.
A six-time all-star, Fregosi posted a career .265 batting average, 151 home runs, 706 runs batted in and .736 on-base-plus slugging percentage.
He said his biggest claim to fame was being the key player in the package the Angels traded to the Mets for a group of players that included hard-throwing pitcher Nolan Ryan.
Fregosi ended his playing career with the Pirates in 1978 and was hired the following day to manage in California.
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