The Boston Athletic Association announced the policy changes Wednesday in advance of the April 21 marathon.
Runners will not be allowed to bring bags. Bags will also not be allowed in certain areas near the start or finish line or along the course.
Runners will be given a chance to check gear on Boston Common on the morning of the marathon to allow them to have a change of clothing at the end of the race. The BAA said it will provide clear plastic bags for that.
Twin bombs placed in backpacks near the 2013 finish line killed three people and injured more than 260. Prosecutors say two spectators were responsible.