The Canucks left wing departed the team's Heritage Classic game at BC Place on Sunday after just six minutes of ice time with an apparent left leg injury. The Canucks would squander a two-goal lead, falling 4-2 to Ottawa.
Sedin, 33, is reportedly undergoing an MRI on Monday while his teammates head out on the road for games Tuesday in Arizona and Thursday in Dallas.
Sedin is tied with twin brother Henrik as the team's leading scorer with 40 points, despite not registering a single point in the last 12 games.
Henrik Sedin missed eight games before the Sochi Games break with a rib injury, and was also not available for Sweden during the Olympic tournament.
He returned to Vancouver's lineup last week.
The Canucks are tied in points with Winnipeg and Dallas in eighth place in the conference, but have played more games than both of those clubs.