The Vancouver Police Department's Sgt. Randy Fincham issued a statement just after 9 a.m. PT, saying the incident happened at around 8 a.m. at the intersection of West Hastings Street and Richards Street.
The woman died after being rushed to hospital.
"The Vancouver Police Collision Investigation Unit will be at the scene throughout the day and the intersection at West Hastings and Richards Street remains closed," Fincham said.
The incident is Vancouver's first pedestrian death this year.
Google Maps: West Hastings at Richards