Danniceque Andrews, 14, was last seen Friday morning in the area of Jane Street and Driftwood Avenue.
She is described as black, five feet, four inches tall, 119 pounds, with brown eyes and braided black hair. It is not known what she was wearing.
Police are concerned for her safety.
Anyone with information is asked to contact police at 416-808-4100, or Crime Stoppers at 416-222-TIPS or www.222tips.com.