Ramos (1-1) pitched five innings of five-hit ball in place of Matt Moore, who had Tommy John surgery on Tuesday. Brandon Gomes then tossed three innings and Juan Carlos Oviedo finished.
James Loney had three hits for the Rays, who snapped a three-game losing streak. Ryan Hanigan hit a two-run double to give the Rays a 2-0 lead in the second after Loney singled and Logan Forsythe walked.
White Sox starter John Danks (2-1) struggled with his command and a high pitch count. He allowed four runs and seven hits in 5 2-3 innings. He struck out four, walked four and threw a career-high 123 pitches.
The White Sox threatened in the fifth, loading the bases with a walk, a single and another walk. Jose Abreu grounded out against Ramos to end the inning. Abreu hit a game-ending grand slam in Chicago's 9-6 victory over the Rays on Friday.
YANKEES 4, ANGELS 3
NEW YORK (AP) — John Ryan Murphy hit his first big league homer and drove in three runs, Dellin Betances earned his first win in the majors and the Yankees bounced back against the Angels.
David Robertson posted his first save since coming off the disabled list. Mike Trout singled with one out in a nervy ninth and stole second, but Robertson retired Albert Pujols on a flyball and struck out Howie Kendrick to end it.
A day after the Angels homered four times in a 13-1 romp, they started strong when Trout hit a solo shot on the seventh pitch of the afternoon.
Murphy lined a two-out, two-run single in the second that gave the Yankees a 3-1 lead. The backup catcher then homered on the first pitch in the fifth, tagging Hector Santiago (0-4) for a 4-3 lead.
Betances (1-0) took over in the fifth for shaky starter Vidal Nuno and pitched two scoreless innings.
RED SOX 7, BLUE JAYS 6
TORONTO (AP) — A.J. Pierzynski hit his eighth career grand slam and Will Middlebrooks added a solo homer, powering Boston to the road win.
Jose Bautista and Juan Francisco hit solo home runs for the Blue Jays, who have lost a season-high four straight games.
Middlebrooks has five home runs and 10 extra base hits in 13 career games at Toronto's Rogers Centre. He had a three-homer game against the Blue Jays on April 7, 2013.
Clay Buchholz survived a shaky first inning to win for the first time in five starts this season. Buchholz (1-2) allowed three runs and six hits in seven innings. Koji Uehara got four outs for his fifth save.
Blue Jays right-hander Brandon Morrow (1-2) issued a career-worst eight walks in 2 2-3 innings, allowing four runs without giving up a hit.
ORIOLES 3, ROYALS 2, 10 INNINGS
BALTIMORE (AP) — Nick Markakis singled in the winning run in the 10th inning after two throwing errors by pitcher Danny Duffy laid the groundwork for the Orioles' victory.
The Orioles went eight straight innings without scoring before facing Duffy, who had pitched 8 1-3 scoreless innings on the season.
After Duffy (1-1) hit Jonathan Schoop to begin the 10th, the left-hander threw wildly to second base after fielding a bunt by David Lough. Jemile Weeks followed with another bunt, and on this one Duffy's throw went high and wide to first, loading the bases.
Louis Coleman replaced Duffy and struck out Nelson Cruz before Markakis hit an opposite-field liner that landed inside the left-field foul line.
Zach Britton (3-0), the sixth Baltimore pitcher, struck out Jarrod Dyson with two outs and a runner on second in the top of the 10th.
RANGERS 6, MARINERS 3
SEATTLE (AP) — Mitch Moreland drove in Prince Fielder with a tiebreaking sacrifice fly in the eighth inning, and Texas held on for the win.
Aaron Poreda (1-0) pitched two scoreless innings to earn his first victory since June 25, 2009, with the Chicago White Sox. Joakim Soria got three outs for his sixth save in six chances.
The Rangers appeared to be in trouble when they fell behind 3-0 with Felix Hernandez on the mound for Seattle. But they got to the ace for three runs in the fifth and added three more against the Mariners' bullpen.
Hernandez allowed three runs and five hits in six innings. He struck out four and walked three. Charlie Furbush (0-2) got the loss.
Michael Saunders and Kyle Seager homered for the Mariners.
TWINS 5, TIGERS 3
MINNEAPOLIS (AP) — Phil Hughes threw seven strong innings and Josmil Pinto hit his fifth homer, leading Minnesota to the victory.
Hughes (2-1) had six strikeouts with no walks. He retired 16 straight at one point and has won two straight — a welcome sight for a Twins rotation that had produced only six quality starts this season.
Jared Burton pitched a scoreless eighth and Glen Perkins worked the ninth for his sixth save in seven chances.
Detroit led 2-0 before starter Anibal Sanchez left in the third with a blister on his middle finger on his throwing hand, forcing newly recalled Jose Ortega (0-1) into action.
Ortega, who had just arrived from Triple-A Toledo, and Phil Coke then combined to walk six Twins batters — five in the fifth.
ASTROS 7, ATHLETICS 6
HOUSTON (AP) — Dexter Fowler hit a tiebreaking RBI single in Houston's four-run eighth inning, and the Astros held on for the win.
Fowler also had a solo homer as Houston snapped a three-game losing streak. Chris Carter connected for a two-run shot in the second.
The game was tied at 3 when Fowler drove in Marwin Gonzalez with a base hit against Sean Doolittle (0-2). Jason Castro then singled in Jose Altuve, and Fowler and Castro eventually came home on groundouts.
Brandon Moss hit a three-run homer in the Oakland ninth against Jerome Williams (1-1). Nick Punto then singled, but Coco Crisp bounced into a fielder's choice and Raul Valdes struck out John Jaso and Jed Lowrie for his first save.
Houston ended an eight-game losing streak against Oakland, dating to last season. The Astros also improved to 6-25 against the A's overall.