Wainwright (5-2) had allowed six runs in 45 innings coming in, but the Cubs matched the runs total in just five innings against the St. Louis ace, who gave up 10 hits. His ERA rose from 1.20 to 2.16.
The scoreless streak was one inning shy of the career high for Wainwright, who had been 6-0 in 12 previous starts and five relief appearances at Wrigley Field.
Rizzo added a leadoff home run in the fifth against the Cardinals, who have lost 10 of 16.
Travis Wood (2-3) gave up three runs — two earned — and six hits in seven innings, and Hector Rondon pitched a perfect ninth for his second save.
MARLINS 6, DODGERS 3
MIAMI (AP) — Surprising Tom Koehler outpitched Josh Beckett, and the Marlins extended their home winning streak to seven games by beating the Dodgers.
Koehler (3-2) allowed three hits in seven scoreless innings. The right-hander began the year with a career record of 5-11, made the rotation as a fifth starter and now has an ERA of 2.41.
Beckett (0-1) struck out eight but gave up four runs in 6 2-3 innings. He fell to 0-6 in his past 13 starts and remained winless since the end of the 2012 season, even though his ERA this year is 3.14.
The Dodgers arrived in Miami at 6:30 a.m. after playing for more than 8 hours Thursday at Minnesota to earn their first doubleheader sweep in 12 years, and they looked travel-logged while falling behind 6-0. Twice a bloop single dropped among three Los Angeles fielders to allow a run to score.
BREWERS 2, REDS 0
CINCINNATI (AP) — Wily Peralta doubled home two runs — the first RBIs of his career — and repeatedly escaped trouble during his eight innings, leading the Brewers to a victory over the Reds.
The NL Central leaders improved the best record in the majors to 21-9 and opened a 7 1/2-game lead over Cincinnati. The Brewers are 12-3 on the road.
Peralta (4-1) made his fifth quality start of the season, holding the Reds to three hits and a pair of walks while throwing 110 pitches. Francisco Rodriguez retired the three batters he faced for his 14th save in as many chances.
Peralta doubled with two outs in the fifth off Mike Leake (2-3), who left his first pitch over the plate. Leake gave up seven hits and fanned five as he went eight innings for the second time this season.
NATIONALS 5, PHILLIES 3
PHILADELPHIA (AP) — Adam LaRoche's tiebreaking single in the eighth inning helped the Nationals rally from an early deficit to beat the Phillies.
Cliff Lee outpitched Stephen Strasburg, but the Phillies' bullpen struggled again. Mike Adams (1-1) and Jake Diekman allowed three runs and five hits in an inning.
Benches and bullpens emptied in the fifth after Denard Span exchanged words with Lee. Span was upset that Lee threw an inside fastball as he called time-out. After he grounded out, Span stopped between the plate and the mound on his way back to the dugout and said something to Lee. Players ran on the field, but nothing happened.
Lee allowed two runs — one earned — and four hits, striking out five in seven innings.
Jerry Blevins (2-0) retired the two batters he faced in the seventh to earn the win.
GIANTS 2, BRAVES 1
ATLANTA (AP) — Michael Morse and Angel Pagan homered, Tim Lincecum allowed one run over six innings and the Giants beat the Braves.
San Francisco spoiled the season debut of Braves starter Mike Minor with its seventh victory in eight games.
Atlanta has a season-high four-game losing streak.
After missing the first month of the season with left shoulder tendinitis, Minor (0-1) allowed seven hits, two runs, no walks and struck out four.
He trailed 1-0 when Pagan led off the game with his third homer and was down 2-1 in the sixth after Morse added his seventh homer.
Lincecum (2-1) gave up six hits and three walks with four strikeouts and kept Braves hitters off balance by keeping his pitches low in the strike zone and added a sharp curveball and slider.
DIAMONDBACKS 2, PADRES 0
SAN DIEGO (AP) — Bronson Arroyo and two relievers held the punchless Padres to three hits and Aaron Hill hit a two-run single to lead the Diamondbacks to a victory in a matchup of the bottom two teams in the NL West.
The Diamondbacks have the worst record in the majors — 10-22 — and came in with the worst ERA, 5.20. The Padres came with a .217 batting average, worst in the NL and second-worst in the majors.
Arroyo (2-2) lowered his ERA from 7.77 to 6.03. He didn't allow a hit until Yonder Alonso singled to right with one out in the fifth. Until then, the only baserunner was leadoff batter Everth Cabrera, who reached in the first when Arroyo couldn't handle a chopper for an error. Arroyo then proceeded to get 13 straight outs, including when Seth Smith grounded into an inning-ending double play in the first.
ROCKIES 10, METS 3
DENVER (AP) — Charlie Blackmon homered among his three hits, Jorge De La Rosa pitched effectively for six innings and the Rockies beat the Mets for their sixth win in seven games.
Troy Tulowitzki added three hits and three RBIs, and Nolan Arenado extended the majors' longest hitting streak to 22 games with a single in the seventh. The flashy third baseman, whose streak is tied for the third-longest in Rockies history, also made an eye-catching stop of Chris Young's sharply hit grounder down the line in the eighth, finishing the play with an off-balance throw across the diamond.
De La Rosa (3-3) allowed three runs and eight hits, including a two-run homer by Curtis Granderson in the sixth inning. The left-hander struck out four and walked three in winning his third straight since an 0-3 start.
PIRATES 6, BLUE JAYS 5
PITTSBURGH (AP) — Pedro Alvarez hit a tying two-run homer off Sergio Santos in the ninth inning and Starling Marte following one out later with a winning drive into the bullpen in left-centre, giving the Pirates a win over the Blue Jays.
Santos (0-2) entered with a 5-3 lead and allowed a leadoff single to Neil Walker. He struck out Andrew McCutchen, and Alvarez followed with his seventh homer this season. Pinch-hitter Ike Davis flied out, and Marte hit the first game-ending homer of his big league career.
Mark Melancon (1-1) pitched a hitless ninth for the win. After saving his first four save chances this season, Santos has blown three of his last four for the Blue Jays, who have lost seven of their last nine games.
McCutchen had three hits for Pittsburgh, which outhit the Blue Jays 17-10. The Pirates won for just the third time in 13 games and the fifth time in their last 20.