Dezharea Williams, 15, was last seen on Friday at about 7 a.m. ET near Overlea Boulevard Don Mills Road.
She is described as black with a light complexion, five-feet, one-inch tall, weighing 112 pounds, with brown eyes and long black braided hair.
She is believed to be wearing a black leather jacket with grey sleeves, black tights, black shoes and carrying a pink duffle bag.
Police are concerned for her safety.
Anyone with information is asked to contact 54 Division at 416-808-5400, or Crime Stoppers at 416-222-TIPS (8477) or www.222tips.com.