Portions of the interview will also be played throughout the afternoon on CBC Radio One, CBC News Network and starting at 5 p.m. on CBC-TV in Toronto.
The interview comes two days after Ford's public apology for his behaviour that followed a two-month absence from his job while he received treatment for alcohol and drug abuse at a rehabilitation facility in Muskoka.
In his statement Monday, read at an invitation-only news conference, Ford said he felt "ashamed, embarrassed and humiliated" by his behaviour and vowed to make an "unwavering" commitment to "clean living."
Toward the end of his statement, Ford touted his accomplishments in office and promised to continue his fight to control costs at city hall by stopping the "gravy train."
Ford — who is seeking re-election on Oct. 27 — did not take questions after his statement. But for Wednesday, Ford's office has scheduled sit-down interviews with CBC and other media outlets.
The mayor appeared at a handful of Canada Day celebrations on Tuesday, where he was greeted by some supporters and jeered by a few hecklers.
A year of scandal at City Hall
Ford's return to work and apology come after a year of scandal surrounding his office. It began in the spring of 2013, when reporters were offered for sale a video that shows the mayor smoking what appears to be crack cocaine. At the time, Ford denied both using the drug and the existence of the tape.
The story was picked up around the world. Ford was frequently mocked by comedians on late-night television.
Last fall, police announced they had recovered a video file that was consistent with what the media had reported. Within days, Ford admitted that he had smoked crack cocaine, an event he believed had occurred while in one of his "drunken stupors."
His trip to rehab did not come for another six months after that, as Ford ignored calls to step down and made further apologies as other videos emerged showing him acting strangely and in one case making lewd comments about Coun. Karen Stintz.
Ford is seeking re-election against a field of opponents that includes:- Stintz.
- Former NDP MP Olivia Chow.
- Former Ontario Progressive Conservative leader John Tory.
- Former city councillor David Soknacki.