The B.C. Coast Guard and RCMP Emergency Centre received the distress call just before four o'clock.
Police issued a release late Friday that said the four victims, all B.C. residents, were rescued from the water and taken to a local hospital where two were treated for serious, but non-life threatening injuries.
The other two escaped with minor injuries.
Police say the investigation into the crash is in its very early stages, and more information might be released at a later time.