The 72-year-old man was last seen at around 4 p.m. on Monday, in the area of Runnymede Road and Annette Street.
In a Tuesday news release, police said they are concerned about his safety.
Investigators provided the following description of Buttigieg:- Six feet tall
- Weighs approximately 160 lbs.
- Short grey hair, with a black moustache
- Last seen wearing a brown, short-sleeved checkered shirt, blue jeans and black Nike sneakers
Anyone with information on Buttigieg's whereabouts is asked to call police at 416-808-1100 or Crime Stoppers at 416-222-8477.