The lane southbound between Adelaide and Richmond was closed briefly so crews could clean up the shattered glass. The road is now open. The incident is under investigation and no injuries have been reported yet.
The glass fell off a balcony of one of the upper floors of the hotel. This is at least the fourth time there's been falling glass at the hotel.
Last September, one person was injured by falling glass. A 53-year-old man was reportedly hit in the head and was transported to hospital with minor injuries. In 2013, there were two other similar incidents of falling glass from the hotel.
Since then, both the city and the building's owners have investigated the problem but have not determined what's causing it.
Falling glass has also been a problem at the RBC Centre, the Trump Tower and the Festival Tower condominiums at the TIFF Bell Lightbox.
Shangri-La, is a hot spot of the Toronto International Film Festival, and has a popular noodle bar in its lobby.