Raquel Moncrieffe, 12, was last seen on Tuesday afternoon, in the area of Kingston Road and Morningside Avenue.
She is described as five feet six inches tall, with short dark hair. She was last seen wearing acid-wash blue jeans, a black Roots sweater, a white belly top with writing on it and black and grey Nike Jordan running shoes.
Police believe she is still in the Malvern neighbourhood.
Investigators ask anyone with information on Moncrieffe’s whereabouts to call the Toronto police’s 43 Division at 416-808-4300 or Crime Stoppers at 416-222-8477.