The intersection is expected to be closed until Aug. 11.
The temporary closure means that drivers will have to take other routes.
One major change to TTC service will involve the splitting of the 510 Spadina route into two halves while the work is being done over the next two weeks.
One half will run between Spadina station and Baldwin Street, while the other half will operate between Sullivan Street and Queen's Quay.
Passengers needing to go from Baldwin Street to Sullivan Street, or vice-versa, will have to carry a transfer and walk the distance of the gap between the two halves of the service.
Click on the video below to see a more in-depth explanation on the changes from the TTC's Andy Byford and Brad Ross.
Mobile users can view the video by clicking here.