The veteran receiver was listed in Toronto's starting lineup for its game Friday night in Vancouver against the B.C. Lions.
Owens suffered a leg injury in Toronto's 41-27 loss to the Edmonton Eskimos on Aug. 23 but participated fully in the Argos' two practices this week in Calgary.
Owens has played in just four games this season due to injury. He was sidelined earlier this year with a foot ailment.
Despite his limited playing time, Owens remains Toronto's leading receiver with 35 catches for 431 yards and two TDs.
Toronto (3-8) enters weekend action tied with Hamilton (3-7) and Montreal (3-8) for first in the East Division.
B.C. (7-4) is fourth in the West Division, two points behind Saskatchewan and Edmonton (both 8-3) and two points ahead of fifth-place Winnipeg (6-6).