The airline has already filled up three planes with passengers who were stuck in the vacation destination of Los Cabos following the devastation Hurricane Odile inflicted on Mexico's Baja peninsula.
Friday's flight to Calgary — which is open to all stranded Canadians at no charge — was set to leave Los Cabos around 2:30 p.m. MT.
The federal government's website for Canadians travelling or living abroad is advising Canadians who want to be evacuated from the area to get to the Los Cabos airport.
The airline said only it expects there will be about 50 passengers on the final flight.
A similar flight on Thursday brought about 118 people home.
All regular scheduled flights to and from Los Cabos between Sept. 17 and Sept. 21 have been cancelled.
Hundreds of Canadians are already back home after fleeing the area.
Mexican authorities are still struggling to restore services and calm residents five days after Hurricane Odile knocked out power, water and phone service — sparking widespread looting.
The federal co-ordinator for the affected area in Baja California Sur state says 200 electricity workers have been dispatched to the area. However, power had been restored to only about 20 per cent of customers in the twin resort cities of Los Cabos.