Hooks, a versatile cast member on SNL alongside Dana Carvey and the late Phil Hartman from 1986 to 1991, was renowned for her skewering impressions of politicians and celebrities, including Hillary Clinton, Nancy Reagan, Kathie Lee Gifford and Tammy Faye Bakker.
She left the show to join the cast of CBS sitcom Designing Women, but made regular SNL cameo appearances in subsequent seasons in the 1990s.
Hooks had a cameo in 1992's Batman Returns, a recurring role as Vicki Dubcek on NBC's 3rd Rock from the Sun and lent her voice to play Apu's wife Manjula in Fox's hit animated series The Simpsons. Most recently, she played Vera Maroney in NBC's 30 Rock.
Her representatives did not give a cause of death.
On mobile? Watch Jan Hooks sing to a monkey as Kathie Lee Gifford on SNL