RCMP say Highway 63 was closed in both directions near Wandering River for much of Friday afternoon.
Police say the driver of the SUV, who was from Edmonton, died of his injuries en route to hospital.
Investigators believe his vehicle crossed the centre line on an undivided section of the highway before crashing into the northbound truck.
Police say the highway has reopened, but traffic is moving slowly through the area.
Earlier this month Premier Jim Prentice promised that Highway 63 — known as "Death Highway'' for the high number of fatal collisions over the years — will be twinned by the fall of 2016.