Toronto police say the man was riding southbound on Victoria Park Avenue, when he was struck while attempting to cross the O'Connor Drive intersection, at 3:18 p.m. on Tuesday.
The man was rushed to hospital, where he later died. His name has not been released.
Police say the pickup truck was in the midst of making a right-hand turn from Victoria Park Avenue onto O'Connor Drive at the time of the collision.
The collision remains under investigation. Anyone with information is asked to contact police at 416-808-1900.