Lupul reportedly stepped on a stick at Thursday’s practice and fell, breaking his right hand, but was able to complete the workout.
The 31-year-old left-winger was hoping to play but the pain got progressively worse and an x-ray was taken when the team arrived in Columbus for Friday’s game against the Blue Jackets. That’s when the fracture was discovered.
Matt Frattin took Lupul’s spot in the lineup in Columbus.
Lupul missed time last season with foot and groin injuries and had his season cut short in April when it was announced he required knee surgery.
Since being acquired in a trade with Anaheim during the 2010-11 season, Lupul has missed time for shoulder, elbow, foot and groin injuries.
Before Friday, he had played in each of Toronto’s nine games this season and scored two goals and three points.